A Coenzima Q10 (CoQ10), também denominada por Ubiquinona, é uma substância natural, essencial e existente em praticamente todas os tecidos do corpo. É lipossolúvel e a sua principal função é a de dar vigor ao seu organismo.

A CoQ10 foi identificada pela primeira vez em 1957, e a sua estrutura química determinada em 1958. A investigação relacionada ao papel da CoQ10 no desempenho fundamental para as células produzirem energia foi contemplado com o Prêmio Nobel de Química em 1978.

O Coenzima Q10 Balance é uma fórmula que conjuga a CoQ10 com o Selénio, numa dosagem concreta e biodisponível, que oferece uma eficácia na sua caminhada ao longo da idade com um total bem-estar, essencial para encarar a vida com toda a fluidez e segurança e responder aos desafios do quotidiano com vigor e vitalidade.

O Coenzima Q10 balance contribui para:
• Proteger as células contra as oxidações indesejáveis (Selénio*)
• Normalizar a espermatogénese (Selénio*)
• Normalizar o funcionamento do sistema imunitário (Selénio*)
• Normalizar o funcionamento da tiroide (Selénio*)

(*) – Alegações de saúde permitidas segundo o REGULAMENTO (UE) N. o 432/2012 da COMISSÃO de 16 de maio de 2012

Toma Diária: 1 cápsula.
Modo de tomar: 1 cápsula antes do pequeno almoço com um copo de água.

Bibliografia
Beyer RE. The participation of coenzyme Q in free radical production and antioxidation.Free Radic Biol Med. 1990;8(6):545–65. doi: 10.1016/0891-5849(90)90154-B. Littarru GP, Nakamura R, Ho L, Folkers K, Kuzell WC. Deficiency of coenzyme Q10 in gingival tissue from patients with periodontal disease. Proc Natl Acad Sci U S A.1971;68:2332–35. Hansen IL, Iwamoto Y, Kishi T, Folkers K, Thompson LE. Gingival and leucocytic deficiencies of coenzyme Q10 in patients with periodontal disease. Res Commun Chem Pathol Pharmacol. 1976;14:729–38. Venardos KM, Perkins A, Headrick J, Kaye DM. Myocardial ischemia-reperfusion injury, antioxidant enzyme systems, and selenium: a review. Curr Med Chem. 2007;14(14):1539–49. Epub 2007/06/23. . Navas-Acien A, Bleys J, Guallar E. Selenium intake and cardiovascular risk: what is new?Curr Opin Lipidol. 2008;19(1):43–9. Epub 2008/01/17. doi:10.1097/MOL.0b013e3282f2b261 . Sanoobar M, Eghtesadi S, Azimi A, Khalili M, Khodadadi B, Jazayeri S, et al. Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial. Nutr Neurosci. 2014. Epub 2014/03/14. doi: 10.1179/1476830513Y.0000000106 . Alehagen U, Johansson P, Bjornstedt M, Rosen A, Dahlstrom U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedi citizens. Int J Cardiol. 2013;167(5):1860–6. Epub 2012/05/26. doi:10.1016/j.ijcard.2012.04.156 . Duran-Prado M, Frontinan J, Santiago-Mora R, Peinado JR, Parrado-Fernandez C, Gomez-Almagro MV, et al. Coenzyme Q10 protects human endothelial cells from beta-amyloid uptake and oxidative stress-induced injury. PLoS One. 2014;9(10):e109223 doi:10.1371/journal.pone.0109223 ; Lee BJ, Tseng YF, Yen CH, Lin PT. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutr J. 2013;12(1):142 doi:10.1186/1475-2891-12-142 ; Ankola DD, Viswanad B, Bhardwaj V, Ramarao P, Kumar MN. Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy?Eur J Pharm Biopharm. 2007;67(2):361–9. doi: 10.1016/j.ejpb.2007.03.010. Mabuchi H, Nohara A, Kobayashi J, Kawashiri MA, Katsuda S, Inazu A, et al. Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Atherosclerosis. 2007;195(2):e182–9. doi: 10.1016/j.atherosclerosis.2007.06.010. Watts GF, Playford DA, Croft KD, Ward NC, Mori TA, Burke V. Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus.Diabetologia. 2002;45(3):420–6. doi: 10.1007/s00125-001-0760-y. Bentinger M, Tekle M, Dallner G. Coenzyme Q-biosynthesis and functions. Biochem Biophys Res Commun. 2010;396:74–79. Bhagavan HN, Chopra RK. Coenzyme Q10 absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006;40:445–453. Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician. 2005;72:1065–1070. Brea-Calvo G, Rodríguez-Hernández A, Fernández-Ayala DJ, Navas P, Sánchez-Alcázar JA. Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines. Free Radic Biol Med. 2006;40:1293–1302. Bresolin N, Doriguzzi C, Ponzetto C, Angelini C, Moroni I, et al. Ubidecarenone in the treatment of mitochondrial myopathies: a multi-center double-blind trial. J Neurol Sci.1990;100:70–78. Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am J Stedman, Thomas – Dicionário médico, Editora Guanbara Koogan s.a., Rio de Janeiro, Brasil, 1996 Jacob, Stanley – Anatomia e Fisiologia Humana, Editoria Guanabara Koogan S.A., Rio de Janeiro, Brasil, 1990. Silverthorn, Dee - Fisiologia Humana, Uma abordagem integrada, Editora Manole, Lda, Brasil, 2003. Guyton, Arthur – Fisiologia humana. Cordero MD, Alcocer-Gómez E, de Miguel M, Cano-García FJ, Luque CM, et al. Coenzyme Q10 a novel therapeutic approach for Fibromyalgia? Case series with 5 patients. Mitochondrion. 2011;11:623–625. Olszewer, Efrain – Tratado de medicina Ortomolecular e Bioquímica médica, Ícone editora, São Paulo, Brasil, 2002 Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q10effect on clinical improvement. PLoS One. 2012;7:e35677. Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001;20:591–598.DiMauro S, Quinzii CM, Hirano M. Mutations in coenzyme Q10 biosynthetic genes. J Clin Invest. 2007;117:587–589. Domae N, Sawada H, Matsuyama E, Konishi T, Uchino H. Cardiomyopathy and other chronic toxic effects induced in rabbits by doxorubicin and possible prevention by coenzyme Q10. Cancer Treat Rep. 1981;65:79–91. Folkers K, Littarru GP, Ho L, Runge TM, Havanonda S, Cooley D. Evidence for a deficiency of coenzyme Q10 in human heart disease. Int Z Vitaminforsch. 1970;40:380–390. Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci USA. 1985a;82:901–904. Folkers K, Wolaniuk J, Simonsen R, Morishita M, Vadhanavikit S. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proc Natl Acad Sci USA. 1985b;82:4513–4516. Haas RH. The evidence basis for coenzyme Q therapy in oxidative phosphorylation disease. Mitochondrion. 2007;7(suppl):S136–S145. Hargreaves IP, Duncan AJ, Heales SJ, Land JM. The effect of HMG-CoA reductase inhibitors on coenzyme Q10 possible biochemical/clinical implications. Drug Saf.2005;28:659–676. Hathcock JN, Shao A. Risk assessment for coenzyme Q10 (Ubiquinone) Regul Toxicol Pharmacol. 2006;45:282–288. Hernández-Ojeda J, Cardona-Muñoz EG, Román-Pintos LM, Troyo-Sanromán R, Ortiz-Lazareno PC, et al. The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study. J Diabetes Complications.2012;26:352–358. Hidaka T, Fujii K, Funahashi I, Fukutomi N, Hosoe K. Safety assessment of coenzyme Q10 (CoQ10) Biofactors. 2008;32:199–208. Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes.Eur J Clin Nutr. 2002;56:1137–1142. Horstink MW, van Engelen BG. The effect of coenzyme Q10 therapy in Parkinson disease could be symptomatic. Arch Neurol. 2003;60:1170–1172. Jolliet P, Simon N, Barré J, Pons JY, Boukef M, et al. Plasma coenzyme Q10concentrations in breast cancer: prognosis and therapeutic consequences. Int J Clin Pharmacol Ther. 1998;36:506–509. Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine XV. Inhibition of coenzyme Q10-enzymes by clinically used adrenergic blockers of beta-receptors. Res Commun Chem Pathol Pharmacol. 1977;17:157–164. Kwong LK, Kamzalov S, Rebrin I, Bayne AC, Jana CK, et al. Effects of coenzyme Q10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med. 2002;33:627–638. Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med. 1994b;15(Suppl):S265–272. Lee BJ, Huang YC, Chen SJ, Lin PT. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition. 2012a;28:250–255. Lee BJ, Huang YC, Chen SJ, Lin PT. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. Nutrition. 2012b;28:767–772. Lee J, Boo JH, Ryu H. The failure of mitochondria leads to neurodegeneration: do mitochondria need a jump start? Adv Drug Deliv Rev. 2009;61:1316–1323. Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10 recent developments. Mol Biotechnol. 2007;37:31–37. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10 an update. Nutrition.2010;26:250–254. Liu J, Wang L, Zhan SY, Xia Y. Coenzyme Q10 for Parkinson's disease. Cochrane Database Syst Rev. 2011. p. CD008150. Lönnrot K, Pörsti I, Alho H, Wu X, Hervonen A, Tolvanen JP. Control of arterial tone after long-term coenzyme Q10 supplementation in senescent rats. Br J Pharmacol.1998;124:1500–1506. López-Lluch G, Rodríguez-Aguilera JC, Santos-Ocaña C, Navas P. Is coenzyme Q a key factor in aging? Mech Ageing Dev. 2010;131:225–235. Mancini A, Balercia G. Coenzyme Q10 in male infertility: physiopathology and therapy.Biofactors. 2011;37:374–380. Mancini A, De Marinis L, Oradei A, Hallgass ME, Conte G, et al. Coenzyme Q10concentrations in normal and pathological human seminal fluid. J Androl. 1994;15:591–594. Mancini A, De Marinis L, Littarru GP, Balercia G. An update of Coenzyme Q10implications in male infertility: biochemical and therapeutic aspects. Biofactors.2005;25:165–174. Mancuso M, Orsucci D, Volpi L, Calsolaro V, Siciliano G. Coenzyme Q10 in neuromuscular and neurodegenerative disorders. Curr Drug Targets. 2010;11:111–121. Mas E, Mori TA. Coenzyme Q10 and statin myalgia: what is the evidence? Curr Atheroscler Rep. 2010;12:407–413. Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med.1997;18(suppl):S137–S144. Prakash S, Sunitha J, Hans M. Role of coenzyme Q10 as an antioxidant and bioenergizer in periodontal diseases. Indian J Pharmacol. 2010;42:334–337. Quinzii CM, DiMauro S, Hirano M. Human coenzyme Q10 deficiency. Neurochem Res. 2007;32:723–727. Roffe L, Schmidt K, Ernst E. Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review. J Clin Oncol. 2004;22:4418–4424. Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, et al. Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia. 2002;22:137–141. Rusciani L, Proietti I, Rusciani A, Paradisi A, Sbordoni G, et al. Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression. J Am Acad Dermatol. 2006;54:234–241. Sacconi S, Trevisson E, Salviati